Research - PPP001: Pancreatic Polypeptide (PP), PPY

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PPP001: Pancreatic Polypeptide (PP), PPY

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Price: 285 € / 0.25 ml

Polyclonal Antibodies

Origin:	Rabbit

Isotype:	Ig

Clone:	polyclonal

Format:	liquid conc.

Quantity:	0.25 ml

Working concentration:	1/50-1/100

Presentation:	Stabilized serum

Immunogen:	Bovine PP conjugated to BSA

Specificity:	Pancreatic polypeptide (PP)

Species Specificity:	Human, bovine, mouse, rat

General Information:	The pancreatic polypeptide (PP)(66 aa) is the pro-hormone of the pancreatic hormone (36 aa) found in PP- or F-cells of the Langerhans-islets of the pancreas. The concentration of PP in blood increases postbrandially of protein rich food. PP inhibits the enzyme and hydrogen carbonate production of the pancreas, the motility of the intestine and the efflux from the gallbladder.

Special properties:	The antibody may be used to detect PP in intact pancreas or in carcinoids of the lung and intestine.

Positive control:	Pancreas

Pre-treatment:	No protease pre-treatment required

Applications:	IHC (C,P)

Incubation time:	60 min at RT or 18 hr at 2-8°C

Secondary reagents:	We recommend the use of BIOLOGO's Universal Staining System DAB (Art. No. DA005) or AEC (Art.-No. AE005), if higher sensitivity is required VECTASTAIN Elite ABC (Art. No. PK-6102), ABC AP (Art. No. AK-5002) or VECTOR ImmPress Mouse IgG systems are applicable.

Storage:	2-8°C

References:
1. L.-I. Larsson F. Sundler and R. Håkanson (1975) Immunohistochemical localization of human pancreatic polypeptide (HPP) to a population of islet cells Cell and Tissue Research Volume 156(2) 167-171.

Notes:
*BIOLOGO's antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!