Research - NAP001-0.5: Napsin A

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NAP001-0.5: Napsin A

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Price: 230 € / 0.5 ml

Polyclonal Antibody

Origin:	Rabbit

Isotype:	IgG

Clone:	polyclonal

Format:	liquid conc.

Quantity:	0.5 ml

Concentration:

Working concentration:	1/50-1:200 (IHC)

Presentation:	Purified antibody in PBS, BSA, Na N3 (0,09%)

Immunogen:	Purified human Napsin

Specificity:	Human Napsin A

Species Specificity:	Human, Mouse

General Information:	Napsin is a pepsin-like aspartic proteinase, in the A1 clan of the AA clade of proteinases. There are two closely related napsins, napsin A and napsin B. Napsin A is expressed as a single chain protein with the molecular weight of approximately 38 kDa. Immunohistochemical studies revealed high expression levels of napsin A in human lung and kidney but low expression in spleen. Napsin A is expressed in type II pneumocytes and in adenocarcinomas of lung. The high specificity expression of napsin A in adenocarcinomas of lung is useful to distinguish primary lung adenocarcinomas from adenocarcinomas of other organs.

Special properties:	The polyclonal antibody against Napsin A is well suited for the detection of Napsin A in lung and kidney

Positive control:	Primary adenocarcinoma of the lung or kidney

Pre-treatment:	Formaldehyde-fixed material requires heat induced epitope retrieval. The use of TRIS/EDTA buffer pH.9 (Art. No. DE006) is recommended.

Applications:	IHC(C, P)

Secondary reagents:	Anti-rabbit IgG:Biotin conjugate (code no. ZU101) in conjunction with Streptavidin-HRPO (code no. ZU054) or VECTOR ImmPress rabbit IgG Kit (code no. MP-7401).

Storage:	2-8°C

UniProt Accession No.: O96009 (NAPSA_HUMAN)

References:
1. Akihiro Suzuki, Noriharu Shijubo, Gen Yamada, Shingo Ichimiya, Masaaki Satoh, Shosaku Abe and Noriyuki Sato (2005) Napsin A is useful to distinguish primary lung adenocarcinoma from adenocarcinomas of other organs Pathology - Research and Practice Volume 201, pp 579-586

2. Gomoluch, B. M. (2003) Die Wertigkeit von Napsin A in der Diagnostik primärer pulmonaler Adenokarzinome, Inauguraldissertation Universität Bochum S. 1-113.

Notes:
BIOLOGO antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

The preservative sodium azide has been added in very small quantities. Nevertheless, it may be harmful to health and the reagent should be used only by trained personnel. For waste disposal, please refer to national regulations.