Research - MSH001: Alpha-MSH (Melanophore Stimulating Hormone)

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MSH001: Alpha-MSH (Melanophore Stimulating Hormone)

Price: 295 € / 0.25 ml

Polyclonal Antibodies

Origin:	Rabbit

Isotype:	Ig

Clone:	polyclonal

Format:	liquid conc.

Quantity:	0.25 ml

Working concentration:	1/50-1/100

Presentation:	Stabilized serum

Immunogen:	Synthetic alpha-MSH conjugated to BSA

Specificity:	alpha-MSH

Species Specificity:	Human, mouse, rat, pig

General Information:	Alpha-MSH (Melanophore Stimulating Hormone) is a 13 aa Oligopeptide, which is produced in most vertebrates in the intermediate lobe of the pituitary. In humans it is produced by ACTH-cell of the pituitary. It regulates the dispersion of Melanin in skin melanophores and is important for the adaptation of the skin to different environments and lighting conditions. It is part of the pre-opiomelanocortin, which is also split to ACTH in posttranslational processing. Alpha-MSH is also present in the brain and functions as a immunomodulatory and anti-inflammatory substance.

Special properties:	The antibody is well suited for the immunohistochemical detection of alpha-MSH in tissue sections

Positive control:	Hypophysis of human, mouse, rat, pig and other ver

Pre-treatment:	Paraffin-fixed tissues don't require antigen unmasking.

Applications:	IHC (C,P)

Incubation time:	IHC(P) 60 min at RT or 2-8°C over night

Secondary reagents:	Biotinylated anti-Rabbit IgG (Art. No. ZU101) in combination with Streptavidin:HRPO (Art. No. ZU054) or Streptavidin:AP (Art. No. ZU051) and a suitable substrate.

Storage:	2-8°C

References:
1. Xue CY, Li L, Guo LL, Li JH, Xing X. (2010) The involvement of alpha-melanocyte-stimulating hormone in the hyperpigmentation of human skin autografts. Burns. . [Epub ahead of print]

2. Meyer KC, Brzoska T, Abels C, Paus R. (2009) The alpha-melanocyte stimulating hormone-related tripeptide K(D)PT stimulates human hair follicle pigmentation in situ under proinflammatory conditions. Br J Dermatol. 160(2):433-7

Notes:
*BIOLOGO's antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!