Research - MBD011-S: Beta-Defensin-1 (MBD-1)

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MBD011-S: Beta-Defensin-1 (MBD-1)

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Price: 370 € / 100 µl

Polyclonal Antibodies

Origin:	Rabbit

Isotype:	Serum

Clone:	polyclonal

Format:	lyophilisate

Quantity:	100 µl

Working concentration:	1:1000 - 1:5000 WB, 1:10000 - 1:50000 ELISA

Presentation:	Rabbit serum lyophilized with PBS and sodium azide 0.05%

Immunogen:	Synthetic 16 aa N-terminal peptide of mouse beta-defensin-1

Specificity:	Mouse beta-defensin-11 (MBD-1), cross-reactivity with rat expected, no cross-reaction with HBD-1

Species Specificity:	Mouse

General Information:	Mammalian defensins are Cys-rich antimicrobial peptides which specifically react against Gram-negative bacteria. Originally defensins were isolated from hemolysates, but they can also be found on the cell surface of epithelia of the urogenital tract, lung, and trachea. In leukocytes defensins are stored in granules being released into phagolysosomes for the destruction of incorporated microorganisms. Amino acid sequences of alpha-defensins 1-4 (HNP1-4) and beta-Defensins 1-4 (HBD1-4) are known. Beta-defensin-1 and beta-defensin-2 share 34% amino acid sequence homology.

Special properties:	The peptide fragment of MBD-1 used for immunisation shows 87% sequence homology rat beta-defensin-1 but no homology to other known defensins.

Positive control:	Kidney or bladder epithelia

Applications:	ELISA, RIA, IHC not established

Secondary reagents:	We recommend the VECTASTAIN Elite ABC Kit Rabbit IgG (Ref. PK-6101) or BioPrime Universal Staining Kits (Ref. AE005 and DA005).

Storage:	-20'°C'

References:
1. Huttner KM, Kozak CA, Bevins CL. The mouse genome encodes a single homolog of the antimicrobial peptide human beta-defensin 1. FEBS Lett. 1997 Aug 11;413(1):45-49.

2. Ganz T. Defensins and host defense. Science. 1999 Oct 15;286(5439):420-1.

Notes:
BIOLOGO antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.