Research - LHR001: LH-RH (Luteinizing Hormone-Releasing Hormone)

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LHR001: LH-RH (Luteinizing Hormone-Releasing Hormone)

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Price: 280 € / 0.25 ml

Polyclonal Antibodies

Origin:	Rabbit

Isotype:	Ig

Clone:	polyklonal

Format:	liquid conc.

Quantity:	0.25 ml

Working concentration:	1/50-1/100

Presentation:	Stabilized serum

Immunogen:	Synthetic LH-RH conjugated to BSA

Specificity:	LH-RH (Luteinizing Hormone-Releasing Hormone)

Species Specificity:	Human, mouse, rat

General Information:	The Luteinizing Hormone-Releasing Hormone (LH-RH, syn. Gonadorelin, Gonadoliberin, Luliberin) is a dekapeptide that is produced in the pre-optic area of the hypothalamus. It is transported by axonal transport and is released into the portal veins of the pituitary to stimulate LH and FSH secretion.

Special properties:	The antibody is well suited for the detection of LH-RH in hypothalamic tissue.

Positive control:	Hypothalamus

Pre-treatment:	Paraffin-fixed tissues don't require antigen unmasking.

Applications:	IHC (C,P)

Incubation time:	IHC(P) 60 min at RT or 2-8°C over night

Secondary reagents:	Biotinylated anti-Rabbit IgG (Art. No. ZU101) in combination with Streptavidin:HRPO (Art. No. ZU054) or Streptavidin:AP (Art. No. ZU051) and a suitable substrate.

Storage:	2 - 8°C or aliquots at -20°C.

References:
1. Herbison AE, de Tassigny X, Doran J, Colledge WH. (2010) Distribution and postnatal development of Gpr54 gene expression in mouse brain and gonadotropin-releasing hormone neurons. Endocrinology 151(1):312-21.

2. Jennes L, Stumpf WE. (1986) Gonadotropin-releasing hormone immunoreactive neurons with access to fenestrated capillaries in mouse brain. Neuroscience;18(2):403-16.

3. Andersson K, Fuxe K, Agnati LF, Eneroth P, Camurri M. (1984) Luteinizing hormone-releasing hormone increases dopamine turnover in the lateral palisade zone of the median eminence and reduces noradrenaline turnover in the nuc. preopticus medialis of the hypophysectomized male rat. Neurosci Lett. 45(3):253-8.

Notes:
*BIOLOGO's antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!