Research - LGR004 (KG137): LGR4 (GRP48) clone 12H6

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LGR004 (KG137): LGR4 (GRP48) clone 12H6

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Price: 650 € / 50 µg

Monoclonal Antibody

Origin:	Mouse

Isotype:	IgG2a, k

Clone:	12H6

Format:	liquid conc.

Quantity:	50 µg

Concentration:	0.25 mg/ml

Presentation:	Protein G purified antibody in PBS with 2% Bock Ace as stabilizer and 0,1% Proclin as bacteriostat

Immunogen:	Recombinant human LGR4

Specificity:	Human LGR4

Species Specificity:	Human, other species not yet tested

General Information:	LGR4, also known as GPR48, is a member of the leucine-rich repeat (LRR)-containing G protein-coupled receptor (LGR) family. LGR4 is composed of the extracellular domain containing 18 LRRs, the seven-transmembrane region. LGR4 is widely expressed in ovary, testis, adrenal, placenta, thymus, spinal cord, and thyroid in human. The LGR4 knockout mice show intrauterine growth retardation, remarkable decreases in the kidney and liver weights, suggesting that LGR4 plays important role for embryonic growth, especially for kidney and liver development. A study, by use of the LGR4 hypomorphic mutant mice, showed that the homozygous male is infertile, showing morphologic abnormality in both the testes and the epididymides. Moreover, it has been demonstrated that up-regulation of LGR4 enhances carcinoma cell invasiveness and metastasis.

Special properties:	This antibody is specific to LGR4 and will be useful for research on embryonic growth, postnatal development, tumor invasiveness and metastasis.

Positive control:	Human ovary, testis, adrenal, placenta

Applications:	WB, FACS, other applications not tested yet

Secondary reagents:	Anti-mouse IgG conjugates, e.g. anti-mouse IgG (H+L) biotinylated (VECTOR Art. No. BA-2000) in combination with Streptavidin:HRPO (Art. No. SA-5004) or Streptavidin:AP (Art. No. SA-5100) and a suitable substrate.

Storage:	-20°C

UniProt Accession No.:

References:
1. Hoshii T. et al.: LGR4 Regulates the Postnatal Development and Integrity of Male Reproductive Tracts in Mice. Biol Reprod.2007 Feb;76(2):303-13. Epub 2006 Nov 1.

2. Gao Y. et al.: Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis. Cancer Res. 2006 Dec 15;66(24):11623-31.

3. Mazerbourg et al. (2004) Leucine-rich repeat-containing, G-protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality. Mol. Endocrinol. 18(9); 2241-2254.

4. Hsu SY. et al. : Characterization of two LGR genes homologous to gonadotropin and thyrotropin receptors with extracellular leucine-rich repea and a G protein-coupled, seven-transmembrane region. Mol Endocrinol. 1998 Dec;12(12):1830-45.

Notes:
** BIOLOGO products may be used as research reagents for in vitro investigations only. They are not intended for clinical diagnostic use. Gebrauch wird vom Hersteller ausgeschlossen.