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Products> BioPrime Antibodies

Code N°


CA102: Calcitonin




Price: 450 € / 1 ml

Monoclonal Antibody

Origin:Rabbit
 
Isotype:IgG
 
Clone:SP17
 
Format:liquid conc.
 
Quantity:1 ml
 
Working concentration:1:25 - 1:50
 

Thyroid Medullary Carcinoma stained with CA102, DAB, Heamatoxylin


Presentation:Purified antibody in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**. The volume is sufficient for at least 100 immunohistochemical tests (100 µl working solution / test). Use appropriate antibody diluent e.g. BIOLOGO Art. No. PU002.
 
Immunogen:Synthetic human Calcitonin aa 1-32
 
Specificity:Human Calcitonin
 
Species Specificity:Human, Dog, Horse, Mouse, Monkey, Pig, Sheep, Rat
 
General Information:Calcitonin is a peptide hormone of 32 aa length, which is produced by C-cells of the thyroid gland. The hormone is responsible for the homeostasis of Calcium in blood and for Calcium uptake into bone cells.
 
Special properties:The antibody, which is specific for human Calcitonin, may be used for the detection of C-cells in the thyroid glands. It is also suitable for the investigation of C-cell hyperplasia and for the detection of medullary thyroid carcinoma in which calcitonin is over-expressed.
 
Positive control:Thyroid gland, Medullary Thyroid Carcinoma
 
Pre-treatment:Pretreatment of deparaffinized tissue with heat-induced epitope retrieval is recommended.
 
Applications:IHC (C, P)
 
Incubation time:60 min at RT
 
Secondary reagents:We recommend the use of BIOLOGO's Universal Staining System DAB (Art. No. DA005) or AEC (Art. No. AE005), for higher sensitivities VECTASTAIN Elite ABC (Art. No. PK-6101) or ABC AP (Art. No. AK-5001) systems are applicable.
 
Storage:2-8°C
 
UniProt ID: P01258 CALC_HUMAN
 

References:
1. Talerman A., Lindeman J., Kievit-Tyson P.A., et al. (1979) Demonstration of calcitonin and carcinoembryonic antigen (CEA) in medulary carcinoma of the thyroid (MCT) by immunoperoxidase technique. Histopathol. 3; 503-510.

2. Holm R., Nesland J.M., Attramadal A. et al. (1989) Null cell adenomas of the pituitary gland. An immunohistochmical study. J. Pathol. 153; 213-217.

3. Grunditz T., et al. (1986) Calcitonin gene-related peptide in thyroid nerve fibers and C-cells: effect on thyroid hormone secretion and response to hypercalcemia. Endocrinology 119; 2313-2324.

4. Luts A. et al. (1994) Calcitonin, CGRP and helodermin in endocrine cells of the developing rat lung. Regulatory Peptides 51; 121-129.



Notes:
*BIOLOGO's antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!

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