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Products> BioPrime Antibodies

Code N°


AC100: ACTH, Corticotrophin




Price: 310 € / 1 ml

Polyclonal Antibodies

Origin:Rabbit
 
Isotype:Serum
 
Clone:polyclonal
 
Format:liquid conc.
 
Quantity:1 ml
 
Working concentration:1:50-1:100
 
Presentation:Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**. The volume is sufficient for at least 100 immunohistochemical tests (100 µl working solution/test). Use appropriate antibody diluent e.g. BIOLOGO Art .No. PU002.
 
Immunogen:Synacthen, ACTH (1-24)
 
Specificity:ACTH 1-24, no reactivity with CLIP (ACTH 17-39)
 
Species Specificity:Human, pig, rat
 
General Information:The adrenocorticotropic hormone ACTH is produced by cells of the pituitary gland as a pro-opiomelanocortin precursor. It is secreted into the blood as biological active ACTH (1-39). It is stimulating the synthesis and secretion of steroid hormones like cortisol and corticosterone from the adrenal cortex of mammalians and interrenal glands of other vertebrates. It is essential for the maintenance of glucose and salt in the blood.
 
Special properties:The antibody against ACTH is suitable for the detection of the hormone in tissue slices of the pituitary and in ectopic ACTH producing cells as it may occur in SCLC (small cell lung carcinoma).
 
Positive control:Pituitary, pituitary adenoma
 
Pre-treatment:No protease treatment required
 
Applications:IHC(P)
 
Incubation time:60 min at RT
 
Secondary reagents:We recommend the use of BIOLOGO's Universal Staining System DAB (Art. No. DA005) or AEC (Art.-No. AE005), if higher sensitivity is required VECTASTAIN Elite ABC (Art. No. PK-6101) or ABC AP (Art. No. AK-5001) systems are applicable.
 
Storage:2-8°C
 

References:
1. Bjartell A., et al. (1987) Gamma2-MSH-like immunoreactivity in porcine pituitary and adrenal medulla. An immunochemical and immunocytochemical study. Regul. Pept. 19; 291-306.



Notes:
*BIOLOGO's antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!

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