Research - PR105: Prolactin, human

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PR105: Prolactin, human

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Price: 290 € / 1 ml

Monoclonal Antibodies

Origin:	Mouse

Isotype:	IgG1

Clone:	INN-hPRL-1

Format:	liquid conc.

Quantity:	1 ml

Concentration:	100 µg/ml

Working concentration:	1:50

Presentation:	Antibody solution in stabilizing phosphate buffer pH 7.3. Contains 0.09 % sodium azide**. The volume is sufficient for at least 100 immunohistochemical tests (100 µl working solution / test). Use appropriate antibody diluent e.g. BIOLOGO Art .No. PU002.

Immunogen:	Purified hPRL

Specificity:	Human prolactin, no cross-reactivity with hPL (placental lactogen) and hGH (growth hormone) in RIA and ELISA

Species Specificity:	Human

General Information:	Prolactin is the luteotropic hormone, which is synthesized in the pituitary gland and is released into the blood stream to stimulate the corpus luteum to produce progesterone. During perinatal phase prolactin together with steroid hormones is responsible for the structural changes of the mammary glands and the milk production. Abnormal proliferation of prolactin cells may lead to prolactinoma, which can cause galactorrhoe and infertility in women.

Special properties:	The antibody is suitable for the detection of prolactin producing cells and for the differentiation from other hormone producing cells in the pituitary and pituitary adenoma.

Positive control:	Pituitary

Pre-treatment:	No protease pre-treatment required

Applications:	IHC(P)

Incubation time:	60 min at RT

Secondary reagents:	We recommend the use of BIOLOGO's Universal Staining System DAB (Art. No. DA005) or AEC (Art.-No. AE005), if higher sensitivity is required VECTASTAIN Elite ABC (Art. No. PK-6102) or ABC AP (Art. No. AK-5002) systems are applicable.

Storage:	2-8°C

References:
1. Franks S., Murray M.A.F., Jequier A.M., Steele S.J., Nabarro J.D.N., and Jacobs H.S. (1975) Incidence and significance of hyperprolactinaemia in women with amenorrhoea. Clin. Endocrinol. 4; 597-607.

2. Schott W., Buchfeder M., Fahlbusch R., Herzog A., von Werder K., Kovacs K. (1997) Unusual morphology of a malignant prolactinoma undergoing neuronal differentiation. Exp. Clin. Endocrinol. Diabetes 105 (Suppl. 1) Abstract p039 p. 64.

Notes:
*BIOLOGO's antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.

** The preservative sodium azide is known to be poisonous and potentially hazardous to health. It should be handled only by trained staff. Despite of the product's low azide concentration it must be handled with care. Dispose according to regional rules!