Research - FPR002: FPRL1 (FMLP-R-II)

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FPR002: FPRL1 (FMLP-R-II)

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Price: 670 € / 50 µg

Polyclonal Antibody

Origin:	Mouse

Isotype:	IgG

Clone:	polyclonal

Format:	liquid conc.

Quantity:	50 µg

Concentration:	1 mg/ml

Working concentration:	WB 1 µg/ml, FACS 1 µg/ml

Presentation:	Protein A purified antibody from mouse serum in PBS, pH 7.2

Immunogen:	Recombinant protein, whole sequence of human FPRL1

Specificity:	FPRL1, syn. FMLP-R-II; FPR2

Species Specificity:	Human, other species not yet tested

General Information:	Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4).Subcellular location: Cell membrane; Multi-pass membrane protein.Tissue specificity: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis. Sequence similarities: Belongs to the G-protein coupled receptor 1 family.

Special properties:	This antibody detects FPRL1 in transfected 293T cell lysates by western blot and FPRL1 expressing 293T cells by flow cytometry.

Positive control:	Lung, neutrophils

Pre-treatment:

Applications:	WB, FACS, other applications not tested yet

Secondary reagents:	Anti-mouse IgG:Biotin conjugate (code no. ZU102) in combination with Streptavidin-HRPO (code no. ZU054) and a suitable substrate e.g. DAB (Ref. DA002) or AEC (Ref AE002).

Storage:	-20°C

UniProt Accession No.: P25090 (FPR2_HUMAN)

References:
1. Bao L., et al. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. Genomics 13:437-440(1992)

2. Perez H.D., et al. "Cloning of a cDNA encoding a receptor related to the formyl peptide receptor of human neutrophils." Gene 118:303-304(1992)

3. Ye R.D., et al. "Isolation of a cDNA that encodes a novel granulocyte N-formyl peptide receptor." Biochem. Biophys. Res. Commun.184:582-589(1992)

Notes:
BIOLOGO antibodies are intended for in vitro research use only. They must not be used for clinical diagnostics and not for in vivo experiments in humans or animals.